Patients in Scotland are set to be the first to test a new drug to treat the devastating effects of cystic fibrosis. Research company NovaBiotics, based in Aberdeen, has been developing a treatment known as Lynovex for the past 18 months to tackle the symptoms of the disease and also keep patients healthier for longer. They now hope to start testing the drug on patients this year, with those in Scotland set to benefit first.
The Cystic Fibrosis Trust said it looked forward to seeing the results of the trial. More than 9,000 people across the UK are affected by CF. The hereditary disorder affects the internal organs, especially the lungs and digestive system, by clogging them with thick sticky mucus, making it hard to breathe and digest food. Only half of those living with cystic fibrosis are likely to live past their late thirties.
The new treatment tackles the symptoms of CF, while also reducing the chances of more damage being caused to the lungs. This could offer patients needing a lung transplant valuable extra time in their wait for organs to become available.
Deborah O'Neil, founder of NovaBiotics, said during their research they realised that the treatment would be good at breaking down what are known as bacterial biofilms - the slimy infections which form in people with CF to try to protect themselves against the immune system and antibiotics. "It seemed to have this property. But we went further and realised that it didn't just break down biofilms but broke down mucus," she said.
"It also had this extra property that it was antibiotic in its own right as well, so not just killing bacteria because it breaks down these biofilm structures, but it actually killed the bacteria directly." The researchers also found that the drug worked with the antibiotics currently used for CF patients and discovered that in combination it made these more powerful.
Dr O'Neil said: "This could mean that the drugs would be used less, reducing the chances of them becoming resistant more quickly. The evidence suggested that with Lynovex you can reduce the amount of antibiotic and that it delivered this effect which means that dosing could go for much longer intervals and you would have to dose less frequently."
So far the drug - which would be taken from a nebuliser or inhaler - has only been tested in the laboratory, but that is set to change this year with the start of patient trials.
Getting the drug ready for use in patients could also be speeded up as the treatment has already been used in another condition - a rare metabolic disease known as cystinosis - meaning many safety tests have already been carried out.
Between 20 and 40 patients are set to take part in first stage of trial. Dr O'Neil said the drug was also expected to be very cheap - maybe only a few hundred pounds, or even less, per patient each year.
Matthew Reed, chief executive of the Cystic Fibrosis Trust, said: "Any new drug that has the potential to significantly improve the lives of people with CF, helping them to live longer and have a better quality of life, is to be welcomed.
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Commercial Collaboration Deal for (Oral) Lynovex® | 5th August 2016
NovaBiotics Announces New Data on Cysteamine (Nylexa™) as an Antimicrobial Resistance Breaker in Multi Drug Resistant Bacteria | 18 June 2016
NovaBiotics Highlights Importance of Co-ordinated Approach to Antimicrobial Resistance | 7th June 2016
NovaBiotics Wins Investment of the Year Award | 5 Feb 2016
Lynovex® Activity in CF sputum & Against the Emerging CF Pathogen, Mycobacterium abscessus | 12 Aug 2015
Phase IIa clinical study results for NovaBiotics' Lynovex® presented at the 38th Annual European Cystic Fibrosis Symposium | 12 Jun 2015
Launch of the BEAM Alliance | 9 Jun 2015
NovaBiotics Quoted in "What Investment" on 11 February | 11 Feb 2015
NovaBiotics Raises £5.0 million in a Private Placement from Woodford Investment Management | 19 Jan 2015
NovaBiotics' Dr Deborah O'Neil Named EY UK Health Products & Services Entrepreneur of 2014 | 7 Oct 2014
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NovaBiotics Receives Orphan Drug Status from the US Food and Drug Administration (FDA) for Lynovex® | 16 Sep 2014
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Precious Cells Biobank Acquires Stem Cell Technology Leader Pharmacells Group | 25 July 2014
NovaBiotics' Dr Deborah O'Neil Wins Entrepreneur of the Year | 27 June 2014
NovaBiotics Initiates Phase IIa Clinical Study for Lynovex in Cystic Fibrosis | 25 June 2014
NovaBiotics' Dr Deborah O'Neil Named EY Scotland Entrepreneur of 2014 | 20 June 2014
NovaBiotics Initiates Development of Orphan Drug in Cystic Fibrosis | 17 December 2013
Pharmacells to expand following funding boost | 24 September 2013
NovaBiotics Enters into Agreement with Taro | 28 August 2013
First patient dosed at Aberdeen Royal Infirmary in major international study | 29 August 2012
Pharmacells in talks to extend reach overseas | 24 January 2012
New hope in cystic fibrosis fight as Scots patients first to test drug | 2 January 2012
NovaBiotics reveals plans for cystic fibrosis drug after EU grants orphan status | 19 December 2011
Pharmacells stores stem cells for teenager paralysed in car crash | 20 October 2011
NovaBiotics Ltd - Presentation at BIO International 2011, Washington DC | 24 June 2011
Launch of Oristem® | 04 June 2011
GBP in Nexxus newsletter, Spring 2011 | 22 March 2011
Patents granted in key territories as Novexatin® moves closer to further clinical development and commercialisation | 21 February 2011
Unblinded Phase IIa Clinical Trial Data Delivers Excellent Results for Novexatin®, Nova... | 5 July 2010
Successful Completion of Phase IIa clinical trial for Novexatin®, IND filing planned for Phase IIb... | 1 May 2010
Commercial Collaboration Deal for (Oral) Lynovex®
5th August 2016
NovaBiotics Announces New Data on Cysteamine (Nylexa™)
18th June 2016
NovaBiotics Wins Investment of the Year Award
5th February 2016
Launch of the BEAM Alliance
9th June 2015
NovaBiotics Quoted in "What Investment" on 11 February
11th February 2015
Showcases increasing investor interest in the global stem cell sector
22nd September 2014